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用于检测有害微生物的一次性光学测试基板 Uusitalo利用拉曼光谱技术开发了微生物细胞的光学检测，通过SERS(表面增强拉曼散射)扩增提高了测量灵敏度。SERS测量基于拉曼散射，其强度通过金属中自由电子的振荡而增加。在一些情况下，该方法可以将样品识别为一个分子的精确水平。使用卷对卷生产方法图案化一次性SERS测量基板，并用薄金镀层涂覆基板。 “在挑战细胞测量的情况下，SERS过程变得越敏感，它在未来的应用就越多。与传统细胞培养相比，它将提供一种快速简便的微生物鉴定方法，并能够快速识别微生物。例如，食品中毒或食品工业生产设施中的快速纯度分析，“Uusitalo说。 她认为，该方法的第一个一般应用将是在爆炸物检测或环境毒素的分析。便携式拉曼测量装置已经在市场上用于分析更大的样品量。未来的研发还将导致便携式SERS测量设备用于测量非常低的样品量。 关键词： 光学测试
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dushunli 2019-08-20 00:13光学测试基本
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mang2004 2019-08-20 00:42原文：
VTT develops disposable optical test substrate for detecting harmful microbes
20/11/2017
Harmful microbes and toxic micromolecules in food and drinking water can cause serious health problems around the world. For her PhD thesis, VTT researcher Sanna Uusitalo has developed a disposable optical test substrate for use in microbial detection. The aim is to enable cost-effective detection of harmful microbes and toxins.
Uusitalo developed the optical detection of microbial cells using Raman spectroscopy to increase measurement sensitivity via SERS (surface-enhanced Raman scattering) amplification. SERS measurement is based on Raman scattering, whose intensity is increased by the oscillation of free electrons in metal. In some cases, the method can identify a sample to a precision-level of one molecule. The disposable SERS measuring substrate is patterned using a roll-to-roll production method and coating the substrate with thin gold plating.
"The more sensitive the SERS process becomes in the case of challenging cell measurements, the more applications it will have in the future. It would provide a fast and simple method of microbial identification compared to traditional cell cultures and enable the fast identification of microbes in cases, say, of food poisoning, or rapid purity analysis in food industry production facilities," says Uusitalo.
She believes that the first general application of the method will be in explosives detection or the analysis of environmental toxins. Portable Raman measuring devices are already on the market for the analysis of larger sample volumes. Future R&D will also lead to portable SERS measuring devices for measuring very low sample volumes.
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lufan 2019-08-20 05:39检测有害微生物的一次性光学测试基板
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刘明欢聪慧 2019-08-20 06:10用于检测有害微生物的一次性光学测试基板
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1014597 2019-08-20 06:30检测有害微生物的光学测试基板
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redplum 2019-08-20 07:57光学测量很重要
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likaihit 2019-08-20 07:58好厉害的
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zhyi119 2019-08-20 08:05有害微生物检测。。。
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songyang1169 2019-08-20 08:06食品和饮用水中的有害微生物和有毒微小分子可能会在全世界造成严重的健康问题。对于她的博士论文，VTT研究员Sanna Uusitalo开发了一种用于微生物检测的一次性光学测试基板。目的是实现经济有效的有害微生物和毒素检测。
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yuchen1019 2019-08-20 08:08检测有害微生物的一次性光学测试基板