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研究人员开发出能在低能红外光下分解的高分子材料 近红外光能穿透皮肤10厘米以下进入身体组织内部，而且能以极高的时空精确度远程实施，在诊断和治疗疾病方面有很大的应用价值，而且低能量的近红外光不会对身体组织造成伤害，但却一直没有与这种波长范围的光响应的生物材料作为载体。领导该研究的艾达·奥姆塔莉解释说，如果有一种材料，受到近红外光照射后会分裂，人们就能在其中装满抗癌药物注入肿瘤，然后用近红外光照射以释放出药物。而目前的近红外响应材料必须在高能近红外光照下才能分解，这样会伤害细胞和组织。 研究小组开发出一种新的聚合物材料，能在低能近红外光照射下发生响应分解。通过一种多悬挂体聚合物保护群的光分解作用，引发了一连串环化作用和重组反应，导致聚合物骨架的降解。而且即使照射能量足以导致大量的聚合物分解，这种材料在分解前后对细胞无伤害。 “这是第一个能响应无害照射而分解成小分子的聚合物材料。”研究人员说，用低能近红外光照射，新材料会破碎成小片，对于周围组织是无毒的。因此可以把它们放入植入式“水凝胶”中（也就是含有各种灵活材料的水），用水凝胶携带能释放药物或成像剂的新型聚合物材料，以响应近红外光的照射。 分享到：
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最新评论
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acronis 2011-11-19 00:21怎么知道长期无毒呢？
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zhz0828 2011-11-19 00:26好啊 希望中国尽早掌握这种技术 应用于临床医学中
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bairuizheng 2011-11-19 01:42药物用途很有潜力.
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mang2004 2011-11-19 01:50
给段英文报道过过瘾。
Scientists are reporting development and successful initial testing of the first practical “smart” material that may supply the missing link in efforts to use in medicine a form of light that can penetrate four inches into the human body. Their report on the new polymer or plastic-like material, which has potential for use in diagnosing diseases and engineer new human tissues in the lab, appears in ACS’ journal Macromolecules.
Adah Almutairi and colleagues explain that near-infrared (NIR) light (which is just beyond what human can see) penetrates through the skin and almost four inches into the body, with great potential for diagnosing and treating diseases. Low-power NIR does not damage body tissues as it passes. Missing, however, are materials that respond effectively to low-power NIR. Plastics that disintegrate when hit with NIR, for instance, could be filled with anti-cancer medicine, injected into tumors, and release the medicine when hit with NIR. Current NIR-responsive smart materials require high-power NIR light, which could damage cells and tissues. That’s why Almutairi’s team began research on development of a new smart polymer that responds to low-power NIR light.
Hit with low-power NIR, their new material breaks apart into small pieces that seem to be nontoxic to surrounding tissue. The researchers envision, for instance, putting the polymer in an implantable “hydrogel,” which is a water-containing flexible material used for tissue engineering and drug delivery. A hydrogel with the new polymer could release medications or imaging agents when hit with NIR. “To the best of our knowledge, this is the first example of a polymeric material capable of disassembly into small molecules in response to harmless levels of irradiation,” say the researchers.
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quanliwei 2011-11-19 08:20希望科技越来越发达
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dafeng3210 2011-11-19 08:49谢谢分享
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bestluyf 2011-11-19 08:57支持啊
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wangjcz 2011-11-19 09:25化学看不懂
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tassy 2011-11-19 09:28嗯,科技发达,怎知长期无毒呢？
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fayezh 2011-11-19 09:47
小白鼠方法呗
